This book constitutes the proceedings of the 6th International Workshop on Simplifying Medical Ultrasound, ASMUS 2025, held in conjunction with MICCAI 2025, the 28th International Conference on Medical Image Computing and Computer-Assisted Intervention. The conference took place in Deajeon, South Korea, on September 23, 2025. 

The 24 full papers presented in this book were carefully reviewed and selected from 41 submissions. They were organized in topical sections as follows:​ 3D Reconstruction and Imaging; Registration, Representation and Generation; Image Acquisition, Segmentation and Interpretability; Classification and Measurements.