Sherman Holmes has a dream: to emulate his hero, Sherlock, and open a prestigious detective agency. With his partner, the practical and secretly cross-dressing John H. Garden, "Holmes and Garden Private Investigators" opens its doors, ready to tackle the most baffling of crimes.

But their grand aspirations are quickly grounded in the mundane. Their first clients aren't master criminals, but worried pet owners searching for a missing Princess Leia, a stolen Prince Rupert, and an elderly woman whose vegetables are vanishing from her allotment. As Holmes fumes over the indignity of "misplaced pussycats" , Garden's keen investigative skills unexpectedly lead them to larger, more dangerous cases, including a car being used without its owner's permission and a bank robbery.
With Holmes's theatrical flair for detection, Garden's surprising competence, and the chaotic charm of their new office run by Garden's no-nonsense mother, Shirley , this comedic duo stumbles, surveils, and sometimes blunders their way to solving crimes far more serious than they initially imagined. "A Matter of Business" proves that even the most ordinary cases can lead to the most extraordinary adventures, especially when you're a Holmes and Garden mystery.