A Perfect Night for Murder is a psychological thriller involving FBI profiler, Antoinette (Toni) Postell. Tasked with analyzing the traits of the killer who preys on lone female joggers in Chicago's Lincoln Park, Toni works tandem with brash homicide detective Jack Autrey. Dubbed "Frosty" by the press, a fifth victim turns up during a blizzard on a December night. This case gains heightened attention when a relative of a prominent city official is also found dead, wearing only a nightgown and bathrobe. The murders, deemed unrelated, quickly push the second killing as a priority, yanking Toni from the serial killings. Meanwhile, Frosty continues his unsettling calls to Toni after each murder, complicating the situation further as she tries to keep their communication secret from her superiors. Compounding her struggles is a haunting figure from her past that threatens her grip on reality. If she can't distinguish between truth and delusion, she risks losing everything she holds dear.