When Gina Ford, the daughter of a prominent Tennessee politician, goes missing from the University of Memphis a week after another girl was murdered on the same campus, police call in the FBI. Nick Hagar, married to his job as Special Agent in Charge, is assigned to the case, and when Gina's body is found, her father demands justice.

Maddie Baxter is the forensic expert running DNA tests from the crime scene. When they come back without a match, Nick asks her to do a familial DNA run that yields a shocking result: the prime suspect is Adam Alexander, the very same guy who broke Maddie's heart when she was in college.

But do scientific advancements tell the whole story? Strand of Deception offers romance, suspense, and a lively debate about the impact of DNA testing, for better or worse, on the United States justice system.