After eight years behind bars, Isabella "Bella" Martínez emerges from prison to a world still ruled by betrayal, power struggles, and blood. Her son, Mateo, is ready to reclaim his place in the streets, while former allies and enemies alike maneuver for dominance. From the deserts of Sinaloa to the streets of New York and the jungles of Medellín, rival queens rise, alliances are tested, and a bloody war erupts over control of the criminal empire.

In a story of vengeance, loyalty, and ambition, Cartel Queens V reveals the brutal reality of power when women rule the underworld—and shows that in the world of cartels, no queen falls alone.