Pestilence, a supernatural entity embodying disease and plague, is deeply frustrated by humanity's perception of them as male and their general misunderstanding of their true nature. Influenced by their sister, Wrath, Pestilence decides to take decisive action to correct this misconception and assert their power. This involves a deliberate plan to sow widespread panic and fear among humans, forcing them to acknowledge the reality and capabilities of the Horsemen. Pestilence's goal is to shatter the ingrained human ignorance and the misgendering they experience, leading to a direct and chaotic confrontation. The core conflict revolves around Pestilence's internal struggle with identity and external struggle for recognition and respect from humanity. By orchestrating a campaign of fear, Pestilence aims to prove their power and force a societal reckoning. The resolution likely involves humans confronting the terrifying reality of Pestilence, leading to a significant shift in their understanding and perception, though the exact outcome of this confrontation and the ultimate consequences remain to be seen within this installment.