Marshall Ritch never asked to survive the accident that claimed the life of his wife Lizzie. He certainly never asked for Dr. Kelvin Lockhart to experiment on him in the name of "saving" him, and he never asked for the mutations that made him a wolfman. Now–assisted by fellow test subject Dallas Boyle and the enigmatic Mrs. Hazel Dell–he is determined to stop Lockhart and his cronies from doing any more damage.

However, they soon find themselves facing off against a new threat as they are attacked by a mysterious woman on a motorcycle—one whose true identity comes as a shock to them all...