No one discipline or person can encompass all the knowledge necessary to solve complex, ill-defined problems, or problems for which a solution is not immediately obvious. The concept of Concurrent Engineering (CE) – interdisciplinary, but with an engineering focus – was developed to increase the efficiency and effectiveness of the Product Creation Process (PCP) by conducting different phases of a product's life concurrently. Transdisciplinary Engineering has transcended CE, emphasizing the crucial importance of interdisciplinary openness and collaboration. This book presents the proceedings of the 28th ISTE International Conference on Transdisciplinary Engineering (TE2021). Held online from 5 – 9 July 2021 and entitled 'Transdisciplinary Engineering for Resilience: Responding to System Disruptions', this is the second conference in the series held virtually due to the COVID-19 pandemic. The annual TE conference constitutes an important forum for international scientific exchange on transdisciplinary engineering research, advances, and applications, and is attended by researchers, industry experts and students, as well as government representatives. The book contains 58 peer-reviewed papers, selected from more than 80 submissions and ranging from the theoretical and conceptual to strongly pragmatic and addressing industrial best practice. The papers are grouped under 6 headings covering theory; education and training; PD methods and digital TE; industry and society; product systems; and individuals and teams. Providing an overview of the latest research results and knowledge of product creation processes and related methodologies, the book will be of interest to all researchers, design practitioners, and educators working in the field of Transdisciplinary Engineering.