Artificial Intelligence (AI) is a central topic in contemporary computer science; one which has enabled many groundbreaking developments that have significantly influenced our society. Not only has it proved to be of fundamental importance in areas such as medicine, biology, economics, philosophy, linguistics, psychology and engineering, but it has also had a significant impact in a number of fields, including e-commerce, tourism, e-government, national security, manufacturing and other economic sectors. This book contains the proceedings of PAIS 2022, the 11th Conference on Prestigious Applications of Artificial Intelligence, held in Vienna, Austria, on 25 July 2022 as a satellite event of IJCAI-ECAI 2022. The PAIS conference invites papers describing innovative applications of AI techniques to real-world systems and problems, and aims to provide a forum for academic and industrial researchers and practitioners to share their experience and insight on the applicability, development and deployment of intelligent systems. A total of 18 full-paper submissions and 4 extended-abstract submissions were received for the 2022 conference, of which 10 full papers and 3 extended abstracts were accepted after rigorous peer review. The topics covered range from autonomous navigation, air traffic control and satellite management to the optimization of industrial processes and human-in-the-loop applications. The book will be of interest to all those whose work involves the innovative application of AI techniques to real-world situations.