Software is an essential enabler for science and the new economy. It creates new markets and directions for a more reliable, flexible and robust society and empowers the exploration of our world in ever more depth, but it often falls short of our expectations. Current software methodologies, tools, and techniques are still neither robust nor reliable enough for the constantly evolving market, and many promising approaches have so far failed to deliver the solutions required. This book presents the keynote 'Engineering Cyber-Physical Systems' and 64 peer-reviewed papers from the 16th International Conference on New Trends in Intelligent Software Methodology Tools, and Techniques, (SoMeT_17), held in Kitakyushu, Japan, in September 2017, which brought together researchers and practitioners to share original research results and practical development experience in software science and related new technologies. The aim of the SoMeT conferences is to capture the essence of the new state-of-the-art in software science and its supporting technology and to identify the challenges such technology will have to master. The book explores new trends and theories which illuminate the direction of developments in this field, and will be of interest to anyone whose work involves software science and its integration into tomorrow's global information society.