Digital technology is now an indispensible part of modern healthcare, and this reliance is only likely to increase, with the healthcare of the future set to become ever more data-driven, decision-supporting, deep, and simply more digital. This book presents the proceedings of the 16th annual conference on Health Informatics Meets Digital Health (dHealth 2022), held on 24 and 25 May 2022 in Vienna, Austria. In keeping with its interdisciplinary mission, the conference series provides a platform for researchers and decision makers, health professionals and healthcare providers, as well as government and industry representatives, to discuss innovative digital health solutions to improve the quality and efficiency of healthcare using digital technologies. The book includes 42 papers covering a wide range of topics and providing an insight into the state-of-the-art of different aspects of dHealth, including the design and evaluation of user interfaces, patient-centered solutions, electronic health/medical/patient records, machine learning in healthcare and biomedical data analytics. Offering the reader an interdisciplinary view of the state-of-the-art and of ongoing research activities in digital health, the book will be of interest to healthcare students and professionals everywhere.