The feeding of a prolific sow is a complex process that involves proper nutrient formulation, feed delivery, and an understanding of the biological challenges that she will undergo within her lifetime. In addition, the timeframe in which a sow within the herd is productive is spent predominantly as pregnant or nursing which diverts nutrients away from her to her offspring. Therefore, the changes in nutrition need to be addressed starting before the female becomes sexually mature once the gilt is weaned. This chapter will highlight important considerations concerning sow nutrition and nutrient recommendations by reproductive phase. In addition, information concerning common management practices will be discussed with scientific literature.