After cheating death yet again, the infamous criminal genius Fu Manchu returns with his most dangerous plot: stealing a secret weapon capable of granting him global power. His relentless adversary, Sir Denis Nayland Smith, pursues him from the shadowy alleys of Cairo to the bright lights of New York.

But every move Smith makes seems only to further Fu Manchu's sinister plans. As the stakes rise and the tension mounts, their rivalry threatens not only their lives—but the fate of the world!