The ACC series explores physiologic and pathophysiologic biochemistry in general and Clinical Chemistry specifically. Complex molecular pathways are elucidated using historical, current and emerging technologies such as biosensor design, metabolomics and proteomics. Identification of novel biomarkers and accurate and precise analysis are fundamental to cutting-edge personalized medicine and treatment. Predictive biomarkers that enable the development of new detection and intervention strategies early in disease are especially important given the aging worldwide population. - The microbiome in carcinogenesis - Metabolomics and proteomics - Biosensor design and microsampling in clinical laboratory diagnosis and TDM