Enzymes Trigger Itch explores the often-overlooked connection between biological detergents and skin irritation. It delves into how enzymes like proteases, lipases, and amylases, while effective at stain removal, can disrupt the skin's natural barrier, leading to itching and other adverse reactions. The book highlights that the increasing use of enzyme-enhanced detergents raises concerns about public health, especially for those with sensitive skin.

The book examines the history of detergent development, tracing the evolution from traditional soaps to enzyme-based formulations, and provides a detailed account of how these enzymes interact with skin cells. Readers will gain insights into the mechanisms by which enzymes penetrate and compromise the skin's integrity, triggering inflammatory responses. It presents research from dermatology, toxicology, and biochemistry, including analysis of patch test results correlated with specific enzyme concentrations.

Divided into three parts, the book first introduces the biochemistry of detergent enzymes and the structure of the skin barrier. The second part presents the direct interaction between enzymes and skin cells. Finally, the book synthesizes the evidence, discussing implications for public health. It offers recommendations for minimizing the risk of detergent-related skin irritation, empowering readers to make informed choices and understand the causes of their skin issues.