Advances in Sustainable Masonry Bricks and Blocks: Design Optimization, Bio-based Material Incorporation, and Industrial Waste Valorization is a comprehensive reference resource that addresses the latest advancements and innovations in this field. This book explores novel sustainable masonry innovations in design optimization, bio-based materials, and industrial waste valorization. Part I investigates novel structural strategies—topological interlocking blocks modeled and fabricated in UHPC with an MCDM framework for reusability, a PRISMA-guided review of hygrothermal performance in insulated composite masonry, and a self-sensing brick system enabling continuous structural health monitoring. Part II delves into bio-reinforcements: Juncus-fiber–stabilized compressed earth blocks, fiber-reinforced soil units, glycoprotein stabilizers inspired by termite mounds, lime-hemp and sugarcane bagasse insulation for CEB walls, waste-glass–infused clay bricks, and rice-husk-ash geopolymer blocks. Part III valorizes community and industrial by-products—paper, plastics, bagasse ash, marble and stone dust, coal ash—into fired and unfired masonry, and applies geopolymers to stabilize earth materials. Across experimental research, systematic reviews, full-scale testing, and case studies, it advances durable, high-performance bricks and blocks with reduced environmental impact. - Addresses the latest research findings and practical applications related to sustainable masonry materials - Introduces cutting-edge approaches such as topological interlocking blocks, self-sensing masonry elements, bio-inspired stabilizers, and geopolymer-enhanced composites. - Combines experimental research, systematic literature reviews, multi-criteria decision-making models, full-scale hygrothermal testing, and case studies to evaluate performance, durability, environmental impact, and reusability.