Set across several decades, The Jew from Berlin follows Aaron, a Jewish economist who graduates from Humboldt University in 1930 and joins the Bundesbank. However, as antisemitism rises in Germany, he flees with his family to Austria, where he partners with an Austrian entrepreneur, Hans, to establish a business. Their enterprise flourishes but eventually collapses amid financial instability and growing Nazi influence.

The novel weaves multiple storylines involving crime, revenge, and power struggles. Aaron's descendants and associates become entangled in organized crime, religious conflicts, and the search for identity. Louis, Aaron's son, gets involved with the Illuminati, while his grandson Scar is manipulated by the Mafia into committing murder. Jean Pierre, a ruthless criminal, rapes an immigrant named Rusha, who later marries Scar, believing him to be the father of her child. As Rusha seeks vengeance against Jean Pierre, the web of deceit, betrayal, and violence tightens.

The story culminates in a fiery showdown where long-standing rivalries and betrayals come to a dramatic end. As the past and present collide, characters face their fate in an explosive finale that intertwines crime, history, and personal redemption.