"Aztec Empire Collapse" offers a compelling examination of how one of Mesoamerica's most powerful civilizations succumbed to Spanish conquest in just two years. Moving beyond simplistic explanations, the book meticulously analyzes three critical factors that led to the empire's downfall: Hernán Cortés's strategic military campaigns, the devastating impact of smallpox, and internal political divisions that weakened the Aztec response to foreign threats.

Drawing from both Spanish and indigenous sources, including recently discovered archaeological evidence, the book reveals how the Spanish strategically exploited existing political tensions within the empire. A particularly fascinating insight is the critical role played by the Tlaxcalans, whose support proved instrumental in the Spanish victory.

The devastating impact of smallpox is thoroughly documented, with evidence showing it killed approximately 40% of Tenochtitlan's population within a single year, including crucial military and political leaders. The book's interdisciplinary approach combines military history, epidemiology, and political analysis to provide a comprehensive understanding of this pivotal historical event.

Through careful examination of primary sources and archaeological findings, readers gain insight into how multiple factors converged to facilitate the Spanish conquest. The narrative progresses from examining pre-conquest Aztec society through the various stages of collapse, concluding with an analysis of its lasting impact on colonial Latin America and modern Mexico.