Last Words follows Chicago police Detective Myles Hanson as he navigates a world of crime and unsettling revelations. After a nighttime raid on a drug lab ends in a deadly shootout, Myles is convinced to transfer to another unit. His first case in Violent Crimes is unlike any he's faced before. Maria Peski, a midwife with a quiet life, is savagely murdered.

But that's not the only mystery haunting him. Myles begins experiencing chilling visions and inexplicable phenomena. He begins to hear the final words of the dead, whispers carried on the wind, fragments of unfinished thoughts from those who have passed. As the voices reveal clues no one else can uncover, Myles teams up with his streetwise and relentless partner, Tank Brewer, to piece together the secrets that the dead have left behind.

When a second murder rocks the city with startling similarities, Myles is forced to accept what he fears most: some clues lie beyond the realm of the living. As the line between the supernatural and the real begins to blur, Myles and his partner, Tank Brewer, must untangle a web of deceit, violence, and spectral warnings before the killer strikes again.