This book aims to propose a suitable contingency plan that can minimize the negative effects of future health crises while strengthening the resilience and adaptability of SMEs. The starting point of this work is based on the work of the research project No. 221N283, jointly funded by TÜBİTAK and NARD. This project is part of an integrated approach from the laboratory to the market, with the aim of analyzing and promoting practical and strategic solutions for the development of SMEs in a crisis context. Following the results obtained, the scientific research team sought to broaden its scope of investigation by addressing the challenges that small and medium-sized enterprises (SMEs) face during global crises. This is a crucial issue in a context where economic sustainability and security are increasingly threatened by unforeseen events such as global epidemics.