The tale unfolds with the daring abduction of a woman from Fort Henry by a ruthless band of renegades and hostile Ohio Valley Indians. In response, the courageous duo of Lewis Wetzel and Jonathan Zane embark on a relentless pursuit of the kidnappers. With grim determination, they track the trail into the unforgiving wilderness, fully aware that this difficult journey may be their final expedition. As they near the trail's end, they brace themselves for the most harrowing and bloody battle they have ever faced.