In a world where environmental conditions have forced humanity to take refuge below the Earth's surface, "normal" life is made possible thanks to the advent of Re:Anima, artificial bodies that allow users to walk in the light of the sun-with some caveats. There are those who would seek to exploit Re:Anima technology for their personal gain, and it's up to Kara Kamikigi, his partner Shinano Nagano, and the Enforcement Bureau to deal with these menaces. While the danger they face may not always be mortal, the peril of contending with the darkness in people's hearts is very real...