Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies. - Covers both the fundamental principles of toxicology and unique aspects of major organ systems - Revised edition with new chapters on topics such as new approaches in testing strategies, novel in vitro models such as organ on a chip, and microphysiological systems to name a few - Includes computational approaches, 'omics', new approaches to risk and safety assessment, harmonization, artificial intelligence, and the microbiome - Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts