Sorghum producers are faced with the simultaneous problems of low yields, difficult access to inputs, and are at the bottom of the marketing chain hence the lowest prices received. So a yield increasing strategy needs to confront all of these constraints. This chapter reports on the field research of a programme combining both agronomic and economic components. The programme initially included four Sahelian countries and then focused on Mali as it moved from the pilot to the scaling-up process. In this chapter, we focus particularly on the introduction of new sorghum technologies and the improvement of marketing strategies, as well as the ability of the system to respond to emerging problems.