Douglas River is a nightclub owner in Morgantown, West Virginia. River is also a vampire who, after nearly two centuries of bloodsucking, suddenly discovers he's becoming human again—he's starting to see himself in the mirror, blood makes him sick, daylight doesn't bother him, and other worse things are starting to happen.

Normally, this might not present too much of a problem. But in River's case, he needs to find a cure...fast. He's one of the vampire elite, and after his secret leaks out, other vampires want to kill him so they can usurp his position.

River also has the problem of a team of vampire hunters who've been after him for ages, trying to kill him, too.

The unsympathetic and bloodthirsty River is the sort of fellow who loves being godlike and hates the concept of becoming human. He's desperately looking for his cure and will stop at nothing to end his Vampire's Nightmare.