Koyou rolls up her sleeves to perform yet another revolutionary medical procedure — an appendectomy. But even though she's armed with incredible knowledge and the tools to do it, Koyou is having a hard time convincing people to let her to cut someone open. With the life of a high-profile bureaucrat on the line, Keiun once again stakes his reputation and more on Koyou's skills. Will this first-time operation be a success for the young doctor? Or will it end in tragedy?