Five women, high school friends connected by a shared traumatic experience, come together each year to celebrate their friendship—until one of them sends an invitation that will forever alter the course of their journey. For Emma, Heather, Rachel, Susan, and Yolanda, the ticking of time had begun to ring louder and louder as menopause settled in. Understandably, mid-life brought with it a confusing mix of emotions and questions. That is, until they are presented with a chance to participate in a medical trial—a chance to bring back the zest of their youth and redefine what it means to be 'old'. What follows is a riveting quest of nostalgia, enduring love, loss, and renewal—as the friends journey within to discover a special gift—the beauty of female friendship that stands the test of time.