A first in its field, this guide draws a new conceptualization for high schools from the powerful nexus of research and practice found in the best research hospitals in the country. This original idea is applied to a new set of expectations for the 21st-century high school where all students are prepared for college and careers. Detailed are key insights, such as how to develop a system of innovations and build state university relationships for college programming that is affordable and accountable, and offers a pragmatic approach to high school strategic planning. This book will inspire business, policy, and education leaders to act with a common focus–college acceleration that transforms high schools to improve state and regional economies.