'Titan's Ghosts' deals with a colony on Titan in the mid twenty-sixth century. The premise is one involving a species of aliens living in the belt system of Saturn, and a program on the part of human scientists to abduct and process them for the sake of the Colony's needs. The storyline follows the experience of a single alien who escapes and takes the form of a teenage girl, discovering the human experience while searching for Its fellows.

The body of seventeen year old Kanal Mikli, a science student involved in a surface accident during a school field trip, now hosts a fluorine based gaseous life form which has invaded her nervous system and plays the part of her in Its mission. Doing Its best to mimic human behavior, the native of Saturn's belts uses Its advanced mathematical and information skills to dominate the Colony network and unearth the depth of corruption within the human outpost's society as It attempts to find the others, who are waiting to be processed for the data they can yield the human research team.

In the course of this, the alien meets and allies Itself with a classmate, an engineer, and an infotech, who agree to aid It in Its project. Along the way, the alien is drawn into a minor civil war within the Colony political system, one in which the Executive branch of government pulls a coup, and which the alien and Its comrades are forced to play a part.