Reunion is about how high school friendship was rekindled in adulthood among four friends who find themselves single at their 20-year reunion.

Mike is a successful entrepreneur who has recently lost his wife to breast cancer. Robert, a medium who can communicate with individuals in the afterlife, is having difficulty maintaining a relationship because of his abilities. He receives a message from Mike's wife but feels it is too soon to reveal it. Robert also has communicated with previous classmate Samantha's husband, who lost his life in Afghanistan. Jessica, a single mom of three, was attracted to Mike in high school but they never found the timing to be right. With the help of Robert's abilities as a medium, the four find long-lasting love.