This is an advocacy toward our mission statement to create a "Learning Health System" (LHS) will enable data to be rapidly mobilized, continuously analyzed—and the results subsequently shared—toimprove health care quality, empower public health and biomedical research, and enable clinicians and patients to collaboratively make better-informed health decisions by having scientific data of what works best in every disease. The book builds upon and is a natural progression from the work we have done together over the years to generate strong bipartisan support for the concept and vision of a Learning Health System.