All practical Shelby Stewart wants is to build her PR career at the Boston zoo, and maybe find some nice guys to date. But long-buried memories of a childhood incident keep interrupting her plans, affecting her health one way after another. And when will she actually date someone her friends think is good enough for her?

Ambitious Astrid Ericcson thinks she wrote the book on How to Get Ahead by Flirting. But she is forced to re-visit her career advancement strategy when her PR agency boss takes the innuendos to a whole new level, threatening her job and her safety.

The two frenemies-turned-real-friends reach new highs and lows in life, work and romance, while struggling to make sense of the relationships that torment them. In the end, they realize "almost" counts in much more than horseshoes and hand grenades.