Freudian psychoanalysis has gone through many phases both in Germany and internationally over the last decades. This volume honours these developments on occasion of the 50th anniversary of the Sigmund Freud Institute in Frankfurt.After blossoming worldwide in the 1970s, psychoanalysis as the science of the unconscious went through enormous changes instigated by the globalised information society. Today it is more a "quiet voice of reason" that admonishes us to beware the limits of the feasibility and economic applicability of humans as resources. Modern psychoanalysts are engaged in interdisciplinary, international and intergenerational networks and do their part to study the complex challenges facing us today such as depression, trauma and social desintegration.