This practical manual provides detailed information regarding the methods used in clinical examination of herd/individual animals including history taking related to production disease of animals and laboratory for confirmatory diagnosis of disease. This manual covers all practical aspects of clinical examination of animal and most commonly used laboratory techniques (including ruminal fluid examination, CSF examination, bone marrow and lymph node biopsy, blood transfusion, enzymology and other biochemical parameters) for the diagnosis of metabolic/production diseases.All the methods are given in a very simple way to use directly in the laboratory by even under graduate students. In this manual, students are given a chance to use their mind in solving fundamental questions given at the end of each exercise, and interpret and correlate the results with clinical signs of the diseases, which can be an aid to the confirmatory diagnosis of disease. It will also be helpful for postgraduate students those are doing masters in veterinary medicine.