While her husband, Sherlock Holmes, is off playing detective in London, Irene Adler finds herself having to turn investigator when her friend Renata becomes the prime suspect in the attempted murder of her husband, Luigi Amato. How can she refute the testimony of a credible eyewitness, even though her heart tells her that Renata is innocent? What she needs is tangible evidence, and she's willing to do what she must to obtain it.

When Sherlock finally arrives on the scene, Irene seeks his counsel, and he agrees to assist with her investigation. However their relationship is called into question by Irene's dear friend Sophia, who is not overly fond of Irene's husband nor approving of the way in which they conduct their marriage. Will Irene be able to prove her friend Renata's innocence, or is there a more tangled web of deception at play? And will Sophia's misgivings regarding her marriage bear unfortunate fruit?