A late night call from her mentor sends Selina Moonstone on a mission to Canada, determined to track down a Wendigo and exterminate it.

Accustomed to facing off with the all too real creatures of Native American lore, Selina discovers the Wendigo is someone close to her, forcing her to change gears from destruction to frantic search for a cure. There's no known way to rid a person of the Wendigo spirit once it has begun the consumption of the victim's soul, a lesson she learned the hard way in her youth.

With her loved one's transition to Wendigo imminent, Selina must fight her own lifelong training as a Myth Stalker and find another way. She gathers a mismatched group of allies, including a charming Sin Eater and a conceited mercenary Cryptid hunter from her past, and embarks on a mission to find a solution before it's too late.