Set against the backdrop of modern-day domesticity, "She Watch Channel Zero" follows Carla Parker, a woman who feels trapped in a mundane and unfulfilling marriage. Carla's escape comes in the form of reality TV shows, which she watches obsessively. One night, as she immerses herself in these reality shows, Carla starts fantasizing about murdering her husband, Edward Parker. This thought sparks a series of introspective journeys, where Carla confronts her deepest desires, fears, and the disillusionment she feels with her life.

As the story unfolds, Carla's fantasies become more vivid and disturbing, blurring the lines between reality and illusion. Her obsession with the glamorous, yet often deceitful world of reality TV juxtaposes her own dreary life, fueling her growing discontent and detachment from reality. The narrative weaves through Carla's psychological struggles, exploring themes of identity, escapism, and the impact of media on personal perceptions and relationships.

In a climactic revelation, Carla faces the consequences of her fantasies, leading to a transformational ending that challenges her understanding of herself and her life choices. The novel concludes with Carla's realization of the power of her own agency, prompting her to make a dramatic decision that alters her life's trajectory.