In terms of geopolitics, perhaps the most seminal event of the Middle Ages was the successful Ottoman siege of Constantinople in 1453. The city had been an imperial capital as far back as the 4th century, when Constantine the Great shifted the power center of the Roman Empire there, effectively establishing two almost equally powerful halves of antiquity's greatest empire. Constantinople would continue to serve as the capital of the Byzantine Empire even after the Western half of the Roman Empire collapsed in the late 5th century. Naturally, the Ottoman Empire would also use Constantinople as the capital of its empire after their conquest effectively ended the Byzantine Empire, and thanks to its strategic location, it has been a trading center for years and remains one today under the Turkish name of Istanbul. 

The Ottoman conquest of Constantinople also played a decisive role in fostering the Renaissance in Western Europe. The Byzantine Empire's influence had helped ensure that it was the custodian of various ancient texts, most notably from the ancient Greeks, and when Constantinople fell, Byzantine refugees flocked west to seek refuge in Europe. Those refugees brought books that helped spark an interest in antiquity that fueled the Italian Renaissance and essentially put an end to the Middle Ages altogether.

In the wake of taking Constantinople, the Ottoman Empire would spend the next few centuries expanding its size, power, and influence, bumping up against Eastern Europe and becoming one of the world's most important geopolitical players. It was a rise that would not truly start to wane until the 19th century, and the Ottomans would maintain their empire until the end of World War I.