A corporation in disarray. A water supply compromised. A city on the cusp of a catastrophic mutation event. And its supposed protectors have scattered in all directions.

It's been a month since Scottie Brentson stopped his parents from conquering Greensville. In the aftermath of his battle against Jake and Fiona Brentson, Scottie moves to a lakefront property, only to encounter a never-before-seen mutant. With his mother presumably deceased, Scottie visits his dad in prison to ask about the new mutation. Yet the Brentson patriarch mocks Scottie and reveals a secret to his son, forcing Scottie to once again seek out the help of the Meta-Misfits, a group of fellow mutants dedicated to protecting Greensville from evil.

With multiple crises all vying for his attention, Scottie soon finds himself with the biggest problem of all. The Meta-Misfits have disappeared, while the one ally Scottie still has, Andrew Bruno, can't even control his mutant power of size-shifting.

As Scottie struggles to help Andrew cope with this volatile ability, new META-WEAPONS rise to challenge them, including the most dangerous one of all. Can Scottie overcome all these obstacles by himself?