The de Bruijn graph was defined in 1949 to enumerate the number of closed sequences where each n-tuple appears exactly once as a window in a sequence. Through the years, the graph and its sequences have found numerous applications – in space technology, wireless communication, cryptography, parallel computation, genome assembly, DNA storage, and microbiome research, among others. Sequences and the de Bruijn Graph: Properties, Constructions, and Applications explores the foundations of theoretical mathematical concepts and the important applications to computer science, electrical engineering, and bioinformatics. The book introduces the various concepts, ideas, and techniques associated with the use of the de Bruijn Graph, providing comprehensive coverage of sequence classification, one-dimensional and two-dimensional applications, graphs, interconnected networks, layouts, and embedded systems. Researchers, graduate students, professors, and professionals working in the fields of applied mathematics, electrical engineering, computer science and bioinformatics will find this book useful. - Investigates computational and engineering applications associated with the de Bruijn graph, its sequences, and their generalization - Explores one-dimensional and two-dimensional sequences with special properties and their various properties and applications - Introduces the rich structure of the de Bruijn graph and its sequences, in both mathematical theory and its applications to computing and engineering problems