It is 1917 and Elinor Brooke, a young painter, is studying art in London while her beloved brother Toby serves on the front as a medical officer. When Toby goes missing and is presumed dead, the devastated Elinor refuses to accept it. A letter she finds hidden among his belongings reveals that Toby knew he wasn't coming back and implies that his friend, medic Kit Neville, knows why. But Kit has been horribly disfigured and is reeling from shell shock.

While Elinor tries to piece together the mystery of what happened to her brother, she uses her drawing skills to aid in the surgical reconstruction of those who have suffered unspeakable losses—their faces, their memories, their very minds.

Masterfully written and daringly ambitious, Toby's Room explores at all levels of it means to be human.