Butch Shilton and Joe Peters are on the run and think to hide out in a quiet township. The sheriff comes across them on a wanted poster and once again they have to hightail it. Trouble seems to follow the pals and they end up in the confines of the brutal Los Pecos penitentiary. Breaking out they flee over the border into Mexico only to fall foul of the notorious bandit Barca. They recruit a bunch of escaped convicts to fight Barca only to find they have make a pact with one pack of devils to fight another pack of devils. On top of that the prison guards are out scouring the countryside for the escapees. With enemies closing in on all sides there is nowhere to run. Could this be the end of the trail for Butch and Joe?