This book features a collection of high-quality, peer-reviewed papers presented at the Sixth International Conference on Intelligent Computing and Communication (ICICC 2022) organized by Department of Computer Science and Engineering, G. Narayanamma Institute of Technology and Science (for women) Autonomous, Hyderabad, India, on November 18–19, 2022. It focuses on innovation paradigms in system knowledge, intelligence, and sustainability that can be applied to provide practical solutions to a number of problems in society, the environment, and industry. Further, the book also addresses the deployment of emerging computational and knowledge transfer approaches, optimizing solutions in various disciplines of science, technology, and healthcare.