Inquisitive Gina and her impulsive best friend Mattie know better than to enter abandoned Hungry House. The mansion on the edge of Nowhere, Georgia, has a reputation for 'eating' those who dare to step inside. Yet when another friend and her younger brother disappear after last being seen heading towards Hungry House, Gina and Mattie have no choice but to follow.

Inside, they find every door is a gateway to a new nightmare. Even death is no escape—it only sends the unlucky trespassers back to the start of Hungry House's gauntlet. Their only hope is to survive long enough to confront the house's mistress, an inhuman being whose lust for vengeance is as immortal as she.