Cheating his past-due death by a sinister miracle of science, the immortal mastermind of world-wide crime plans his most daring stroke—theft of the ultimate weapon which will deliver all mankind into his grasp!

And Nayland Smith, his long-time adversary and pursuer, is playing an inexplicable role—for every move Smith makes seems to serve Fu Manchu's fell purpose!

In the shadow-haunted alleys of Cairo and the neon jungle of New York, Smith's desperate daring and Fu Manchu's malignant genius strive in a fateful duel, with human destiny in the balance.