This is an open access book. We warmly invite you to participate in Mathematics and Science Education International Seminar that was held on November 13th, 2021 in Bengkulu – Indonesia. Since participants may come from different countries with variety of backgrounds, the conference is an excellent forum for participants to exchange research findings and ideas on mathematics and science and to build networks for further collaborations..
The disruption era is related to the development of the industrial revolution 4.0 and society 5.0 era. Industrial revolution 4.0 era is marked by massive digital technology development in all aspects. Digital technology transformation is applied  in human life and it is known as human-centered society. Development of digital technology has been influence some aspects such as education, environment, and society. Using digital technology does not only gives negative impacts but also positive impacts. It is important to strengthen sustainable education that has insight into conservation and local wisdom in this era for a better society.