Anuradha was born in 1947 in Thanjavur, Tamil Nadu. Her grandfather R. Balasubramaniam was an actor who inspired Anuradha to become a writer. Anuradha started her career as an artist before making several unsuccessful attempts to get a job with popular magazines. This prompted her to join Mangai, a Tamil magazine after the editor found her writings very interesting. Anuradha's literary career started in 1977 while working for the magazine.

Apart from her literary contributions, she was well known for her "anti-divorce counselling" work. In a career that spanned over 30 years, Anuradha wrote nearly 800 novels and 1,230 short stories. Her works were mainly centered on family and everyday happenings. One of her early works Sirai, won a gold medal for the best short story from Ananda Vikatan. It was adapted into a film of the same name. Following this, her other novels Kootu Puzhukkal, Oru Malarin Payanam and Oru Veedu Iruvasal were adapted into films in various languages such as Tamil, Telugu and Kannada. Oru Veedu Iru Vasal, directed by Balachander won the National Film Award for Best Film on Other Social Issues in 1991. The 1988 Telugu film Oka Baarya Katha based on her work won five Nandi Awards. In addition to films, many of her stories such as Archanai Pookal, Paasam and Kanakanden Thozhi have been adapted into Television serials. She was awarded a gold medal by M. G. Ramachandran, the then Chief Minister of Tamil Nadu.