In a passionate affair with her doctor, Sienna Tiefwald, a transgender therapist, Lhasa Cremieux seeks to discover whether her reincarnation is artificial or natural. Lhasa is a CEO of a small firm that specializes in artificial reincarnation by ingesting a lozenge that affects the DNA of an individual. Is her existence the result of her own experiments or something more profound? Her quest is birthed through a disturbing, recurring vision while living and working in the City of Chicago. The search is textured with deceptive encounters and ultimately leads to the steps of a temple in Tibet where she experiences a disquieting revelation.